RESEARCH OVERVIEW
The DHKIM's Biomaterials for Image Guided MEDicine LAB has focused on developing various therapeutic/imaging carriers for the treatment of cancers. Micro/Nanoparticles and their hybrid derivatives have been exploited as vectors for drug/therapeutic delivery and molecular imaging agents. We are working closely with clinicians, medical scientists, biologist and imaging professionals to translate new therapeutic approaches using various multifunctional carriers and diagnostic imaging technique to the clinical setting.
-Selected Publications
Biofunctionalized Magnetic Vortex Microdiscs for Targeted Cancer Cell Destruction
Dong-Hyun Kim, E.A. Rozhkova, I.V. Ulasov, S.D. Bader, T. Rajh, M.S. Lesniak and V. Novosad.
Nature Materials, 9,165~171 (2010). Featured in “COVER” page.
Magnetic field boosted ferroptosis-like cell death and responsive MRI using hybrid vesicles for cancer immunotherapy
Bo Yu, Bongseo Choi, Weiguo Li and Dong-Hyun Kim*
Nature Communications, 11, 3637 (2020)
Intermolecular Structural Change for Thermo- Switchable Polymeric Photosensitizer,
W Park, S Park, S Cho, H Shin, YS Jung, B Lee*, K Na*, DH Kim*,
Journal of the American Chemical Society (JACS) 138 (34), 10734–10737 (2016)
Synergistic Local Combination of Radiation and Anti-Programmed Cell Death Ligand 1 Immunotherapy using Radiation Responsive Splintery Metallic Nanocarriers
Bongseo Choi, Hyunjun Choi, Bo Yu, Dong-Hyun Kim*
ACS Nano, 14, 10, 13115–13126 (2020)
Magneto-Activation and Magnetic Resonance Imaging of Natural Killer Cells Labeled with Magnetic Nanocomplexes for the Treatment of Solid Tumors
Taehoon Sim, Bongseo Choi, Soon Woo Kwon, Kwang-Soo Kim, Hyunjun Choi, Alexander Ross, and Dong-Hyun Kim*
ACS Nano, 15, 8, 12780–12793 (2021)
Janus Microcarriers for Magnetic Field–controlled Combination Chemotherapy of Hepatocellular Carcinoma, Soojeong Cho, Nam Gi Min, Wooram Park, Shin-Hyun Kim*, and Dong-Hyun Kim*, Advanced Functional Materials, 1901384 (2019).
Selective Coloration of Melanin Nanospheres through Resonant Mie Scattering,
Soojeong Cho, Tae Soup Shim, Ju Hyeon Kim, Dong-Hyun Kim, Shin-Hyun Kim.
Advanced Materials, 2017, 29, 1700256 (2017) –Featured as a Front Cover
Multimodal Magnetic Nanoclusters for Gene Delivery and Directed Migration and Tracking of Stem Cells, Ji Sun Park, Wooram Park, Sin-jung Park, Andrew C. Larson, Dong-Hyun Kim, Keun-Hong Park,
Advanced Functional Materials, 2017, 27(25) 1700396 (2017) –Featured as a Front Cover
Transcatheter intra-arterial infusion of doxorubicin loaded porous magnetic nano-clusters with iodinated oil for the treatment of liver cancer,
MJ Jeon, AC Gordon, AC Larson, JW Chung, YI Kim*, DH Kim*,
Biomaterials 88 (2016) 25-33
Deoxycholate bile acid directed synthesis of branched Au nanostructures for near infrared photothermal ablation, Dong-Hyun Kim*, AC Larson,
Biomaterials 56 (2015) 154–164
Sequential MR Image-Guided Local Immune Checkpoint Blockade Cancer Immunotherapy Using Ferumoxytol Capped Ultralarge Pore Mesoporous Silica Carriers after Standard Chemotherapy,
Bongseo Choi, Huijin Jung, Bo Yu, Hyunjun Choi, Joonseok Lee, Dong-Hyun Kim*,
Small, (2019) –Featured in Front Cover
MRI Visible Drug Eluting Magnetic Microspheres for Transcatheter Intra-Arterial Delivery to Liver Tumors,
Dong-Hyun Kim*, Jeane Chen, Reed A. Omary, Andrew C. Larson,
Theranostics 2015; 5(5):477-488 (2015). - Featured as a “COVER” page.
Branched Gold Nanoparticle Coating of Clostridium novyi-NT Spores for CT-Guided Intratumoral Injection,
W. Park, S. Cho, X. Huang, A. C. Larson*, Dong-Hyun Kim*,
Small, 13(5) 1602722 (2017). –Featured as a Cover of Small
Development of a Pt Nanocluster Assembly to Overcome Chemoresistance and Stemness of Hepatocellular Carcinoma,
Hongping Xia, Daishun Ling, Wooram Park, Fangyuan Li, Yang Du, Youngjin Jang, Xi Hu, Soojeong Cho, Taegyu Kang, Seungmin Baik, Dong-Hyun Kim, Kam Man Hui*, and Taeghwan Hyeon*,
ACS Central Science, 2, 802−811 (2016) –Featured in the main page of journal
Biofunctionalized Hybrid Magnetic/Gold Nanostructures as Catalysts for Photothermal Ablation of Colorectal Liver Metastases
Sarah B. White, Dong-Hyun Kim*, Yang Guo, Weiguo Li, Yihe Yang, Jeane Chen, Venkateswara Gogineni, Andrew C. Larson
Radiology, 2017, 285, 809–819. -Featured Article in "Science to Practice"
Biofunctionalized Magnetic Vortex Microdiscs for Targeted Cancer Cell Destruction
Dong-Hyun Kim, E.A. Rozhkova, I.V. Ulasov, S.D. Bader, T. Rajh, M.S. Lesniak and V. Novosad.
Nature Materials, 9,165~171 (2010). Featured in “COVER” page.
Magnetic field boosted ferroptosis-like cell death and responsive MRI using hybrid vesicles for cancer immunotherapy
Bo Yu, Bongseo Choi, Weiguo Li and Dong-Hyun Kim*
Nature Communications, 11, 3637 (2020)
Intermolecular Structural Change for Thermo- Switchable Polymeric Photosensitizer,
W Park, S Park, S Cho, H Shin, YS Jung, B Lee*, K Na*, DH Kim*,
Journal of the American Chemical Society (JACS) 138 (34), 10734–10737 (2016)
Synergistic Local Combination of Radiation and Anti-Programmed Cell Death Ligand 1 Immunotherapy using Radiation Responsive Splintery Metallic Nanocarriers
Bongseo Choi, Hyunjun Choi, Bo Yu, Dong-Hyun Kim*
ACS Nano, 14, 10, 13115–13126 (2020)
Magneto-Activation and Magnetic Resonance Imaging of Natural Killer Cells Labeled with Magnetic Nanocomplexes for the Treatment of Solid Tumors
Taehoon Sim, Bongseo Choi, Soon Woo Kwon, Kwang-Soo Kim, Hyunjun Choi, Alexander Ross, and Dong-Hyun Kim*
ACS Nano, 15, 8, 12780–12793 (2021)
Janus Microcarriers for Magnetic Field–controlled Combination Chemotherapy of Hepatocellular Carcinoma, Soojeong Cho, Nam Gi Min, Wooram Park, Shin-Hyun Kim*, and Dong-Hyun Kim*, Advanced Functional Materials, 1901384 (2019).
Selective Coloration of Melanin Nanospheres through Resonant Mie Scattering,
Soojeong Cho, Tae Soup Shim, Ju Hyeon Kim, Dong-Hyun Kim, Shin-Hyun Kim.
Advanced Materials, 2017, 29, 1700256 (2017) –Featured as a Front Cover
Multimodal Magnetic Nanoclusters for Gene Delivery and Directed Migration and Tracking of Stem Cells, Ji Sun Park, Wooram Park, Sin-jung Park, Andrew C. Larson, Dong-Hyun Kim, Keun-Hong Park,
Advanced Functional Materials, 2017, 27(25) 1700396 (2017) –Featured as a Front Cover
Transcatheter intra-arterial infusion of doxorubicin loaded porous magnetic nano-clusters with iodinated oil for the treatment of liver cancer,
MJ Jeon, AC Gordon, AC Larson, JW Chung, YI Kim*, DH Kim*,
Biomaterials 88 (2016) 25-33
Deoxycholate bile acid directed synthesis of branched Au nanostructures for near infrared photothermal ablation, Dong-Hyun Kim*, AC Larson,
Biomaterials 56 (2015) 154–164
Sequential MR Image-Guided Local Immune Checkpoint Blockade Cancer Immunotherapy Using Ferumoxytol Capped Ultralarge Pore Mesoporous Silica Carriers after Standard Chemotherapy,
Bongseo Choi, Huijin Jung, Bo Yu, Hyunjun Choi, Joonseok Lee, Dong-Hyun Kim*,
Small, (2019) –Featured in Front Cover
MRI Visible Drug Eluting Magnetic Microspheres for Transcatheter Intra-Arterial Delivery to Liver Tumors,
Dong-Hyun Kim*, Jeane Chen, Reed A. Omary, Andrew C. Larson,
Theranostics 2015; 5(5):477-488 (2015). - Featured as a “COVER” page.
Branched Gold Nanoparticle Coating of Clostridium novyi-NT Spores for CT-Guided Intratumoral Injection,
W. Park, S. Cho, X. Huang, A. C. Larson*, Dong-Hyun Kim*,
Small, 13(5) 1602722 (2017). –Featured as a Cover of Small
Development of a Pt Nanocluster Assembly to Overcome Chemoresistance and Stemness of Hepatocellular Carcinoma,
Hongping Xia, Daishun Ling, Wooram Park, Fangyuan Li, Yang Du, Youngjin Jang, Xi Hu, Soojeong Cho, Taegyu Kang, Seungmin Baik, Dong-Hyun Kim, Kam Man Hui*, and Taeghwan Hyeon*,
ACS Central Science, 2, 802−811 (2016) –Featured in the main page of journal
Biofunctionalized Hybrid Magnetic/Gold Nanostructures as Catalysts for Photothermal Ablation of Colorectal Liver Metastases
Sarah B. White, Dong-Hyun Kim*, Yang Guo, Weiguo Li, Yihe Yang, Jeane Chen, Venkateswara Gogineni, Andrew C. Larson
Radiology, 2017, 285, 809–819. -Featured Article in "Science to Practice"
1. Multifunctional Carriers for CANCER THERAPY
We are developing new micro/nano/composite biomaterials for various cancer treatments. Well-engineered and designed materials will emerge novel and new concept of cancer therapeutics. We are seeking innovative biomaterials and therapeutics which can be combined with image guided medicine technique. Below selected papers are showing novel therapeutic approaches with various materials. This research will have the potential to effectively treat cancer and overcome current cancer treatment methods.
-Selected Publications
a) pH-Sensitive Pt Nanocluster Assembly Overcomes Cisplatin Resistance and Heterogeneous Stemness of Hepatocellular Carcinoma
Hongping Xia, Fangyuan Li, Xi Hu, Wooram Park, Shuaifei Wang, Youngjin Jang, Yang Du, Seungmin Baik, Soojeong Cho, Taegyu Kang, Dong-Hyun Kim, Daishun Ling, Kam Man Hui, Taeghwan Hyeon
ACS Central Science, 2, 802-811 (2016)
b) Intermolecular Structural Change for Thermo-Switchable Polymeric Photosensitizer
W Park, S Park, S Cho, H Shin, YS Jung, B Lee*, K Na*, DH Kim*
Journal of the American Chemical Society (JACS) 138 (34), 10734–10737 (2016)
c) Deoxycholate bile acid directed synthesis of branched Au nanostructures for near infrared photothermal ablation
DH Kim*, AC Larson
Biomaterials 56, 154–164 (2016)
d) MRI Visible Drug Eluting Magnetic Microspheres for Transcatheter Intra-Arterial Delivery to Liver Tumors
DH Kim*, J Chen, RA Omary, AC Larson
Theranostics 5 (5), 477-488 (2015) – Featured as a cover page
e) Temperature‐Sensitive Magnetic Drug Carriers for Concurrent Gemcitabine Chemohyperthermia
DH Kim*, Y Guo, Z Zhang, D Procissi, J Nicolai, RA Omary, AC Larson
Advanced Healthcare Materials 3 (5), 714-724 (2015)
f) Stimuli-responsive magnetic nanomicelles as multifunctional heat and cargo delivery vehicles
D.-H. Kim, E. A. Vitol, J. Liu, S. Balasubramanian, D. J. Gosztola, E. E. Cohen, V. Novosad, E. A. Rozhkova,
Langmuir, 2013, 29 (24), pp 7425–7432 (2013).
g) Biofunctionalized magnetic-vortex microdiscs for targeted cancer-cell destruction
Dong-Hyun Kim, E.A. Rozhkova, I.V. Ulasov, S.D. Bader, T. Rajh, M.S. Lesniak and V. Novosad,
Nature Materials, 9,165~171 (2010). – Featured as a cover page
h) Mechanoresponsive system based on sub-micron chitosan-functionalized ferromagnetic disks
Dong-Hyun Kim, P. Karavayev, E.A. Rozhkova, J. Pearson, V. Yefremenko, S.D. Bader and V. Novosad, “
Journal of Materials Chemistry, 21, 8422-8426, (2011)
-Selected Publications
a) pH-Sensitive Pt Nanocluster Assembly Overcomes Cisplatin Resistance and Heterogeneous Stemness of Hepatocellular Carcinoma
Hongping Xia, Fangyuan Li, Xi Hu, Wooram Park, Shuaifei Wang, Youngjin Jang, Yang Du, Seungmin Baik, Soojeong Cho, Taegyu Kang, Dong-Hyun Kim, Daishun Ling, Kam Man Hui, Taeghwan Hyeon
ACS Central Science, 2, 802-811 (2016)
b) Intermolecular Structural Change for Thermo-Switchable Polymeric Photosensitizer
W Park, S Park, S Cho, H Shin, YS Jung, B Lee*, K Na*, DH Kim*
Journal of the American Chemical Society (JACS) 138 (34), 10734–10737 (2016)
c) Deoxycholate bile acid directed synthesis of branched Au nanostructures for near infrared photothermal ablation
DH Kim*, AC Larson
Biomaterials 56, 154–164 (2016)
d) MRI Visible Drug Eluting Magnetic Microspheres for Transcatheter Intra-Arterial Delivery to Liver Tumors
DH Kim*, J Chen, RA Omary, AC Larson
Theranostics 5 (5), 477-488 (2015) – Featured as a cover page
e) Temperature‐Sensitive Magnetic Drug Carriers for Concurrent Gemcitabine Chemohyperthermia
DH Kim*, Y Guo, Z Zhang, D Procissi, J Nicolai, RA Omary, AC Larson
Advanced Healthcare Materials 3 (5), 714-724 (2015)
f) Stimuli-responsive magnetic nanomicelles as multifunctional heat and cargo delivery vehicles
D.-H. Kim, E. A. Vitol, J. Liu, S. Balasubramanian, D. J. Gosztola, E. E. Cohen, V. Novosad, E. A. Rozhkova,
Langmuir, 2013, 29 (24), pp 7425–7432 (2013).
g) Biofunctionalized magnetic-vortex microdiscs for targeted cancer-cell destruction
Dong-Hyun Kim, E.A. Rozhkova, I.V. Ulasov, S.D. Bader, T. Rajh, M.S. Lesniak and V. Novosad,
Nature Materials, 9,165~171 (2010). – Featured as a cover page
h) Mechanoresponsive system based on sub-micron chitosan-functionalized ferromagnetic disks
Dong-Hyun Kim, P. Karavayev, E.A. Rozhkova, J. Pearson, V. Yefremenko, S.D. Bader and V. Novosad, “
Journal of Materials Chemistry, 21, 8422-8426, (2011)
2. IMAGE GUIDED LOCAL THERAPY-INTERVENTIONAL RADIOLOGY
Interventional radiology is responsible for all the image-guided procedures in the Radiology and Imaging Sciences within clinics. Interventional radiology services are crucial to care and treatment of patients.
Image-guided therapy includes basic bench, in vivo, engineering, and clinical research, combining multimodality tracking and navigation tools to improve accuracy and outcome. Other areas of clinical activity in image-guided therapy include heat activated targeted drug delivery, image guided ablation, microwave, or HIFU, percutaneous injection gene/bacteria therapy, serial biopsy, thrombolytic therapy and Interventional Oncology.
One of the most emerging interventional technique which can be combined with nanomedicine in clinic is Transcatheter arterial chemoembolization (TACE). TACE has been a mainstay for the treatment of HCC patients with intermediate-stage primary liver cancer. TACE can result in high intra-tumoral concentration of chemotherapy drugs. Conventional TACE methods involve the use of lipiodol (oil) mixed with chemotherapy drugs. A recent advancement in the treatment of HCC involves the use of drug-eluting microspheres, which advantageously combine functions of imaging visibility, transcatheter arterial administration for tumor embolic targeting and controlled release of chemotherapeutic drugs. Careful selection of drug carrier materials, chemotherapeutic drugs and fabrication methods will be critical for the translational optimization these new techniques. We are developing drug-eluting nano composite microspheres for transcatheter targeted HCC treatment. These minimally invasive image-guided procedures with multimodal imaging microspheres will result in fewer complications, faster recoveries, and reduced costs versus traditional therapies.
- Selected Publications
a) Transcatheter intra-arterial infusion of doxorubicin loaded porous magnetic nano-clusters with iodinated oil for the treatment of liver cancer
MJ Jeon, AC Gordon, AC Larson, JW Chung, YI Kim*, DH Kim*
Biomaterials 88, 25-33 (2016)
b) Acidic pH-Triggered Drug Eluting Nanocomposites for MRI Monitored Intra-Arterial Drug Delivery to Hepatocellular Carcinoma
W Park, J Chen, S Cho, S Park, AC Larson*, K Na*, DH Kim*
ACS Applied Materials & Interfaces 8 (20), 12711–12719 (2016)
c) MRI Visible Drug Eluting Magnetic Microspheres for Transcatheter Intra-Arterial Delivery to Liver Tumors
DH Kim*, J Chen, RA Omary, AC Larson
Theranostics 5 (5), 477-488 (2015) – Featured as a cover page
d) Poly(lactide-co-glycolide) Microspheres for MRI-Monitored Delivery of Sorafenib in a Rabbit VX2 model
J Chen, White SB, KR Harris, W Li, WT Yap, DH Kim, RJ Lewandowski, LD Shea, AC Larson
Biomaterials, 61, 299-306 (2015).
e) Poly (lactide-co-glycolide) microspheres for MRI-monitored transcatheter delivery of sorafenib to liver tumors
J Chen, AY Sheu, W Li, Z Zhang, DH Kim, RJ Lewandowski, RA Omary, LD Shea, AC Larson
Journal of Controlled Release 184, 10-17 (2014)
Image-guided therapy includes basic bench, in vivo, engineering, and clinical research, combining multimodality tracking and navigation tools to improve accuracy and outcome. Other areas of clinical activity in image-guided therapy include heat activated targeted drug delivery, image guided ablation, microwave, or HIFU, percutaneous injection gene/bacteria therapy, serial biopsy, thrombolytic therapy and Interventional Oncology.
One of the most emerging interventional technique which can be combined with nanomedicine in clinic is Transcatheter arterial chemoembolization (TACE). TACE has been a mainstay for the treatment of HCC patients with intermediate-stage primary liver cancer. TACE can result in high intra-tumoral concentration of chemotherapy drugs. Conventional TACE methods involve the use of lipiodol (oil) mixed with chemotherapy drugs. A recent advancement in the treatment of HCC involves the use of drug-eluting microspheres, which advantageously combine functions of imaging visibility, transcatheter arterial administration for tumor embolic targeting and controlled release of chemotherapeutic drugs. Careful selection of drug carrier materials, chemotherapeutic drugs and fabrication methods will be critical for the translational optimization these new techniques. We are developing drug-eluting nano composite microspheres for transcatheter targeted HCC treatment. These minimally invasive image-guided procedures with multimodal imaging microspheres will result in fewer complications, faster recoveries, and reduced costs versus traditional therapies.
- Selected Publications
a) Transcatheter intra-arterial infusion of doxorubicin loaded porous magnetic nano-clusters with iodinated oil for the treatment of liver cancer
MJ Jeon, AC Gordon, AC Larson, JW Chung, YI Kim*, DH Kim*
Biomaterials 88, 25-33 (2016)
b) Acidic pH-Triggered Drug Eluting Nanocomposites for MRI Monitored Intra-Arterial Drug Delivery to Hepatocellular Carcinoma
W Park, J Chen, S Cho, S Park, AC Larson*, K Na*, DH Kim*
ACS Applied Materials & Interfaces 8 (20), 12711–12719 (2016)
c) MRI Visible Drug Eluting Magnetic Microspheres for Transcatheter Intra-Arterial Delivery to Liver Tumors
DH Kim*, J Chen, RA Omary, AC Larson
Theranostics 5 (5), 477-488 (2015) – Featured as a cover page
d) Poly(lactide-co-glycolide) Microspheres for MRI-Monitored Delivery of Sorafenib in a Rabbit VX2 model
J Chen, White SB, KR Harris, W Li, WT Yap, DH Kim, RJ Lewandowski, LD Shea, AC Larson
Biomaterials, 61, 299-306 (2015).
e) Poly (lactide-co-glycolide) microspheres for MRI-monitored transcatheter delivery of sorafenib to liver tumors
J Chen, AY Sheu, W Li, Z Zhang, DH Kim, RJ Lewandowski, RA Omary, LD Shea, AC Larson
Journal of Controlled Release 184, 10-17 (2014)
3. Image Guided Combinational Immunotherapy
(Interventional Oncology and Immuno-Oncology)
- The local therapies with developed multifunctional platforms could significantly improve the delivery and therapeutic efficiency. Many approaches are proceeding in our lab for combining therapeutics such as chemotherapy, radiotherapy, thermal therapy, immunotherapy, photodynamic therapies with multimodal (MRI/CT/PET) imaging components in a single multifunctional carrier. Various combinations of immune-checkpoint inhibitor-based immunotherapy are highlighted in the clinic because of unique immunogenic tumor microenvironment after conventional cancer treatments. We specially design MRI/CT contrasting multimodal carriers for ICI delivery in the diseased area after conventional cancer treatment. Our newly developed carriers and interventional approaches will have more opportunities for combining current cancer immunotherapy with interventional cancer treatment.
- Multimodal imaging guided embolization for regulating tumor microenvironment in immuno-oncology. Our goal is to develop advanced embolization strategy to achieve exact delivery of therapeutic agents to the target zone by utilizing multimodal imaging. To improve the comprehensive understanding of the correlationship of therapeutics diffusion and its outcomes by multimodal visible materials used in embolization. Design advanced embolization materials for integrating cancer-targeting cell-killing effects with tumor-microenvironment modulators to synergistically eradicate tumor.
- Selected Publications
a) Synergistic Local Combination of Radiation and Anti-Programmed Cell Death Ligand 1 Immunotherapy using Radiation Responsive Splintery Metallic Nanocarriers
Bongseo Choi, Hyunjun Choi, Bo Yu, Dong-Hyun Kim*
ACS Nano (2020)
b) Magnetic field boosted ferroptosis-like cell death and responsive MRI using hybrid vesicles for cancer immunotherapy
Bo Yu, Bongseo Choi, Weiguo Li and Dong-Hyun Kim*
Nature Communications, 11, 3637 (2020)
c) Sequential MR image guided local immune checkpoint blockade cancer immunotherapy using ferumoxytol capped ultra large pore mesoporous silica carriers after standard chemotherapy
Bongseo Choi, Huijin Jung, Bo Yu, Hyunjun Choi, Joonseok Lee, Dong-Hyun Kim*
Small, 15 (52) 1904378 (2019) - Cover Featured Article
4. NANOPARTICLES & MEDICAL IMAGING
Multifunctional Imaging and Therapeutic Carriers: A combination of modern multi-functional nanocomposites with high performance in imaging and therapeutics may be critical to improve therapeutic outcomes. High doses of drugs can be loaded onto drug carriers in a reproducible manner for controlled elution over an extended period of time. Targeted delivery of multifunctional carriers should translate into reduced systemic therapeutic exposures. The development of multifunctional microsphere platforms with superior material properties should significantly improve treatment outcomes. There will be more opportunities for combining therapeutics such as chemotherapy, radiotherapy, thermal therapy, immunotherapy, photodynamic therapies with multimodal (MRI/CT/PET) imaging components in a single multifunctional carrier.
- Selected Publications
a) Multimodal Imaging of Nanocomposite Microspheres for Transcatheter Intra-Arterial Drug Delivery to Liver Tumors
DH Kim*, W Li, J Chen, Z Zhang, RM Green, S Huang, AC Larson
Scientific Reports 6, 29653 (2016)
b) A c(RGDfE) conjugated multi-functional nanomedicine delivery system for targeted pancreatic cancer therapy
J Sun, D-H Kim, Y Guo, Z Teng, Y Li, L Zheng, Z Zhang, A C. Larson and G Lu,
J. Mater. Chem. B, 2015, 3, 1049-1058, (2015)
c) Temperature‐Sensitive Magnetic Drug Carriers for Concurrent Gemcitabine Chemohyperthermia
DH Kim*, Y Guo, Z Zhang, D Procissi, J Nicolai, RA Omary, AC Larson
Advanced Healthcare Materials 3 (5), 714-724 (2015)
d) Stimuli-responsive magnetic nanomicelles as multifunctional heat and cargo delivery vehicles
D.-H. Kim, E. A. Vitol, J. Liu, S. Balasubramanian, D. J. Gosztola, E. E. Cohen, V. Novosad, E. A. Rozhkova,
Langmuir, 2013, 29 (24), pp 7425–7432 (2013).
- Selected Publications
a) Multimodal Imaging of Nanocomposite Microspheres for Transcatheter Intra-Arterial Drug Delivery to Liver Tumors
DH Kim*, W Li, J Chen, Z Zhang, RM Green, S Huang, AC Larson
Scientific Reports 6, 29653 (2016)
b) A c(RGDfE) conjugated multi-functional nanomedicine delivery system for targeted pancreatic cancer therapy
J Sun, D-H Kim, Y Guo, Z Teng, Y Li, L Zheng, Z Zhang, A C. Larson and G Lu,
J. Mater. Chem. B, 2015, 3, 1049-1058, (2015)
c) Temperature‐Sensitive Magnetic Drug Carriers for Concurrent Gemcitabine Chemohyperthermia
DH Kim*, Y Guo, Z Zhang, D Procissi, J Nicolai, RA Omary, AC Larson
Advanced Healthcare Materials 3 (5), 714-724 (2015)
d) Stimuli-responsive magnetic nanomicelles as multifunctional heat and cargo delivery vehicles
D.-H. Kim, E. A. Vitol, J. Liu, S. Balasubramanian, D. J. Gosztola, E. E. Cohen, V. Novosad, E. A. Rozhkova,
Langmuir, 2013, 29 (24), pp 7425–7432 (2013).
Au nanoparticles for Nanomedicine: Au nanoparticles are great of interests in biomedical applications. We reported a newly developed, simple and efficient synthesis of highly branched gold nanoparticles (GNPs) and their potential application for near infrared photothermal ablation therapy. While considered ideal for selective facilitation of photothermal ablation procedures, multiple-branched GNPs with dendritic morphology and primary and secondary branches are considered very difficult to produce. We have critically overcome these difficulties with a salient application of facially amphiphilic bile acids (steroid acids synthesized in hepatocytes). In our study, high efficient photothermal properties of the gold nanostructure were demonstrated in both in vitro and in vivo settings. The deoxycholate bile acid directed synthesis of branched GNPs opens new possibilities for the design of novel materials with customized spectral and structural properties for broad application in nanoelectronics, medicine, ultra-sensitive chemical sensing (SERS), life science, and optical devices.
- Selected Publications
a) Deoxycholate bile acid directed synthesis of branched Au nanostructures for near infrared photothermal ablation
DH Kim*, AC Larson
Biomaterials 56, 154–164
b) Photothermal ablation of pancreatic cancer cells with hybrid iron-oxide core gold-shell nanoparticles
Guo Y., Zhang Z., Kim DH, Li W., Nicolai J., Procissi D., Huan Y., Han G., Omary R. A, Larson A. C.,
International Journal of Nanomedicine 2013:8 3437–3446 (2013)
c) Synthesis of hybrid gold/iron oxide nanoparticles in block copolymer micelles for imaging, drug delivery, and magnetic hyperthermia
DH Kim, EA Rozhkova, T Rajh, SD Bader, V Novosad
IEEE Transactions on Magnetics 45 (10), 4821-4824
- Selected Publications
a) Deoxycholate bile acid directed synthesis of branched Au nanostructures for near infrared photothermal ablation
DH Kim*, AC Larson
Biomaterials 56, 154–164
b) Photothermal ablation of pancreatic cancer cells with hybrid iron-oxide core gold-shell nanoparticles
Guo Y., Zhang Z., Kim DH, Li W., Nicolai J., Procissi D., Huan Y., Han G., Omary R. A, Larson A. C.,
International Journal of Nanomedicine 2013:8 3437–3446 (2013)
c) Synthesis of hybrid gold/iron oxide nanoparticles in block copolymer micelles for imaging, drug delivery, and magnetic hyperthermia
DH Kim, EA Rozhkova, T Rajh, SD Bader, V Novosad
IEEE Transactions on Magnetics 45 (10), 4821-4824
Magnetic Nanoparticles Mediated Local Therapy: Magnetic nanoparticles has been used for multifunctional nano medicine carriers with their versatile properties. Our group has been working on developing new forms of magnetic nanoparticles for use in cancer treatments. One of classical application is magnetic hyperthermia cancer therapy using an external ac magnetic field and magnetic nanoparticles to control the site-specific targeting and heating. This ensures that only the specific cancer site undergoes the therapeutic temperature increase rather than the whole body. In this process, however, the delivery of hyperthermic thermoseeds to a specific and efficient tumor heating with minimal side effects is the biggest challenge facing this type of therapy. Our studies have demonstrated synthesizing and characterizing various magnetic nanoparticles for use as targted hyperthermic thermoseeds.
- Selected Publications
a) Surface-modified magnetite nanoparticles for hyperthermia: Preparation, characterization, and cytotoxicity studies
DH Kim, SH Lee, KH Im, KN Kim, KM Kim, IB Shim, MH Lee, YK Lee
Current Applied Physics 6, e242-e246 (Highlighted Paper in NanoTech News of National Cancer Institute in USA, Sept 5, 2006)
- http://nano.cancer.gov/action/news/nanotech_news_2006-09-05c.asp
b) Heat generation of aqueously dispersed CoFe2O4 nanoparticles as heating agents for magnetically activated drug delivery and hyperthermia
DH Kim, DE Nikles, DT Johnson, CS Brazel
Journal of Magnetism and Magnetic Materials 320 (19), 2390-2396
(Selected as a Most Cited Article published since 2008 in Journal of Magnetism and Magnetic Materials)
c) Targeting to carcinoma cells with chitosan‐and starch‐coated magnetic nanoparticles for magnetic hyperthermia
DH Kim, KN Kim, KM Kim, YK Lee
Journal of Biomedical Materials Research Part A 88 (1), 1-11
d) Biodistribution of chitosan-based magnetite suspensions for targeted hyperthermia in ICR mice
D-H Kim, S Lee, K Im, K Kim, K Kim, K Kim, H Park, I Shim, Y.K. Lee
IEEE transactions on magnetics 41 (10), 4158-4160
- Selected Publications
a) Surface-modified magnetite nanoparticles for hyperthermia: Preparation, characterization, and cytotoxicity studies
DH Kim, SH Lee, KH Im, KN Kim, KM Kim, IB Shim, MH Lee, YK Lee
Current Applied Physics 6, e242-e246 (Highlighted Paper in NanoTech News of National Cancer Institute in USA, Sept 5, 2006)
- http://nano.cancer.gov/action/news/nanotech_news_2006-09-05c.asp
b) Heat generation of aqueously dispersed CoFe2O4 nanoparticles as heating agents for magnetically activated drug delivery and hyperthermia
DH Kim, DE Nikles, DT Johnson, CS Brazel
Journal of Magnetism and Magnetic Materials 320 (19), 2390-2396
(Selected as a Most Cited Article published since 2008 in Journal of Magnetism and Magnetic Materials)
c) Targeting to carcinoma cells with chitosan‐and starch‐coated magnetic nanoparticles for magnetic hyperthermia
DH Kim, KN Kim, KM Kim, YK Lee
Journal of Biomedical Materials Research Part A 88 (1), 1-11
d) Biodistribution of chitosan-based magnetite suspensions for targeted hyperthermia in ICR mice
D-H Kim, S Lee, K Im, K Kim, K Kim, K Kim, H Park, I Shim, Y.K. Lee
IEEE transactions on magnetics 41 (10), 4158-4160